11 Rule-Out Compendium (Summary)

High-level overview of rule-out categories. Use this when a presentation feels off or unsafe; full detail is in the Clean Reference. This is the “don’t miss” map before assigning a primary psychiatric label.

Delirium and Acute Confusional States → acute onset with fluctuating attention.
Substance Intoxication and Withdrawal → sudden change with recent use or cessation.
Medication and Iatrogenic Psychiatric Syndromes → symptoms follow med start or dose change.
Endocrine and Metabolic Mimics → systemic symptoms or unexplained physiologic shifts.
Seizure, Autoimmune, Infectious, and Neurodegenerative Mimics → neurologic signs, seizures, or progressive decline.
Sleep Disorders Masquerading as Psychiatric Illness → prominent sleep disruption or daytime sleepiness.
Pain and Fatigue Syndromes with Bidirectional Causality → chronic pain/fatigue driving mood or function.